کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2586224 | 1130894 | 2010 | 7 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Constituents of Corydalis heterocarpa and their anti-proliferative effects on human cancer cells
دانلود مقاله + سفارش ترجمه
دانلود مقاله ISI انگلیسی
رایگان برای ایرانیان
کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
علوم کشاورزی و بیولوژیک
دانش تغذیه
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Constituents of Corydalis heterocarpa and their anti-proliferative effects on human cancer cells Constituents of Corydalis heterocarpa and their anti-proliferative effects on human cancer cells](/preview/png/2586224.png)
چکیده انگلیسی
Two new coumarins, 1 and 2, along with four known coumarins (3–6) have been isolated from Corydalis heterocarpa. On the basis of spectroscopic and chemical methods, compounds 1 and 2 were elucidated as (2′S,7′S)-O-2-methylbutanoyl-columbianetin and (2′S)-columbianetin-3′-sulfate, respectively. The anti-proliferative activity against human cancer cells of compounds 1–6 isolated from C. heterocarpa was evaluated using a MTT assay and by mRNA expression of several factors related to apoptosis. Among them, compound 2 exerted the more potent anti-proliferative activity compared with the other compounds treated. The potent inhibitory effect of compound 2 was produced by induction of apoptosis through activating Bax, p53 and p21 expressions.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Food and Chemical Toxicology - Volume 48, Issue 2, February 2010, Pages 722–728
Journal: Food and Chemical Toxicology - Volume 48, Issue 2, February 2010, Pages 722–728
نویسندگان
You Ah Kim, Chang-Suk Kong, Sung Su Yea, Youngwan Seo,