کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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2586327 | 1130897 | 2008 | 4 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: Potential analgesic and anti-inflammatory activities of Panax ginseng head butanolic fraction in animals Potential analgesic and anti-inflammatory activities of Panax ginseng head butanolic fraction in animals](/preview/png/2586327.png)
The present study reports the potential anti-rheumatoid activity of Panax ginseng head part. P. ginseng-head part BuOH fraction (PGHB) was safe in acute toxicity (LD50 > 5000 mg/kg) and inhibited the partially acetic acid-induced writhes (approximately 32%, P < 0.05) in mice. PGHB (500 mg/kg) inhibited the acetic acid-induced extravasation of Evan’s blue dye in mice by approximately 20.6% (P < 0.05), and was similar to the suppressive effect of ibuprofen (27.7%) as a positive control drug. Also, PGHB reduced the carrageenan-induced paw edema at 3 h after oral administration, and suppressed the production of serum IL-6 in CIA mice. This suggests that PGHB has potential analgesic and anti-inflammatory activities, and will be the supporting evidence for the potential anti-rheumatoid activity of Korean P. ginseng-head.
Journal: Food and Chemical Toxicology - Volume 46, Issue 12, December 2008, Pages 3749–3752