کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2586572 | 1130905 | 2008 | 4 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: Cytogenetic study in cultured human lymphocytes treated with three commonly used preservatives Cytogenetic study in cultured human lymphocytes treated with three commonly used preservatives](/preview/png/2586572.png)
Potassium sorbate, sodium benzoate and potassium nitrate have been tested for their genotoxic, cytostatic and cytotoxic potential in human peripheral blood cells in vitro. Potassium nitrate has shown no activity in the test system. When potassium sorbate and sodium benzoate were used at concentrations of 2.0, 0.2 and 0.02 mM no cytostatic activity was detected. However, concentrations of 4 and 8 mM have shown a weak cytostaticity. Additionally, a genotoxic activity using the SCE methodology has been observed at 8 mM of sodium benzoate and at 4 and 8 mM of potassium sorbate. No cytotoxic activity has been induced by the three preservatives. Data demonstrate that the preservatives at low concentrations can be considered as non genotoxic under conditions tested.
Journal: Food and Chemical Toxicology - Volume 46, Issue 7, July 2008, Pages 2390–2393