کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2586578 1130905 2008 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Antibacterial and membrane damaging activity of Livistona chinensis fruit extract
موضوعات مرتبط
علوم زیستی و بیوفناوری علوم کشاورزی و بیولوژیک دانش تغذیه
پیش نمایش صفحه اول مقاله
Antibacterial and membrane damaging activity of Livistona chinensis fruit extract
چکیده انگلیسی

Livistona chinensis is used in traditional Chinese medicine as an anticancer agent. Experimental studies have shown the antiproliferative and antiangiogenic properties of extracts of L. chinensis fruits and seeds. In the present study, qualitative phytochemical composition of L. chinensis fruits was investigated. We hypothesized that the presence of high concentration of phenolic compounds with astringent properties may result in bacterial cell death. Hence, antibacterial activity of an aqueous extract of L. chinensis fruits was investigated against Staphylococcus aureus. The antibacterial activity was attributed to DNA, enzyme and protein denaturing properties of the phenolic compounds present in the extract. The extract also resulted in increased membrane permeability. The antibacterial, DNA and enzyme denaturing and membrane damaging activity was limited to an acid-precipitable fraction of the extract and these effects were abrogated in presence of proteins. The membrane damaging activity of phenolic compounds was also observed in leucocytes. In conclusion, this study reported the antibacterial activity of the fruits of L. chinensis due to their high content of phenolic compounds.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Food and Chemical Toxicology - Volume 46, Issue 7, July 2008, Pages 2429–2434
نویسندگان
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