کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2586743 1130909 2008 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Genotoxic effects of tanshinones from Hyptis martiusii in V79 cell line
موضوعات مرتبط
علوم زیستی و بیوفناوری علوم کشاورزی و بیولوژیک دانش تغذیه
پیش نمایش صفحه اول مقاله
Genotoxic effects of tanshinones from Hyptis martiusii in V79 cell line
چکیده انگلیسی

The genotoxic effect of two tanshinones isolated from roots of Hyptis martiussi Benth (Labiatae) was studied using V79 (Chinese hamster lung) cells by the alkaline comet assay and micronucleus test. Tanshinones were incubated with the cells at concentrations of 1, 3, 6 and 12 μg/mL for 3 h. Tanshinones were shown to be quite strongly genotoxic against V79 cells at all tested concentrations. The data obtained provide support to the view that tanshinones has DNA damaging activity in cultured V79 cells under the conditions of the assays.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Food and Chemical Toxicology - Volume 46, Issue 1, January 2008, Pages 388–392
نویسندگان
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