کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2586780 1130910 2008 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Activation of EpRE-mediated gene transcription by quercetin glucuronides depends on their deconjugation
موضوعات مرتبط
علوم زیستی و بیوفناوری علوم کشاورزی و بیولوژیک دانش تغذیه
پیش نمایش صفحه اول مقاله
Activation of EpRE-mediated gene transcription by quercetin glucuronides depends on their deconjugation
چکیده انگلیسی

Quercetin is a flavonoid reported to have health-promoting properties. Due to its extensive metabolism to glucuronides in vivo, questions were raised if studies conducted with quercetin aglycone, stating its health-promoting activity, are of actual relevance. Here we show that glucuronides of quercetin, and its methylated forms isorhamnetin and tamarixetin, can induce EpRE-mediated gene expression up to 5-fold. Furthermore, evidence is presented that EpRE-mediated gene induction by these glucuronides involves their deglucuronidation. This indicates that although quercetin-derived glucuronides are the major metabolites present in the systemic circulation, deglucuronidated derivatives are the active compounds responsible for their beneficial EpRE-mediated gene expression effects.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Food and Chemical Toxicology - Volume 46, Issue 6, June 2008, Pages 2128–2134
نویسندگان
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