کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2587477 1130929 2008 9 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Mechanisms of star fruit-induced acute renal failure
موضوعات مرتبط
علوم زیستی و بیوفناوری علوم کشاورزی و بیولوژیک دانش تغذیه
پیش نمایش صفحه اول مقاله
Mechanisms of star fruit-induced acute renal failure
چکیده انگلیسی

We have previously discovered that star fruit can induce oliguric acute renal failure. To investigate the mechanisms of star fruit-associated acute oxalate nephropathy, the nephrotoxic effect of star fruit was examined in both cellular experiments and animal models. We evaluated renal function, pathological changes in kidney tissues and apoptotic effects using terminal deoxynucleotidyl transferase nick-end labeling (TUNEL) assay in four groups of rats – a control group (CG), fed with tap water (1); a star fruit group (SG), fed with star fruit juice naturally containing 0.2 M oxalate (2); and oxalate groups (OxG), fed with 0.2 M (3) or 0.4 M (4) oxalate solution. The effects of both star fruit juice and oxalate on MDCK cells were also analyzed by flow cytometry. We found that the mean creatinine clearance was significantly lower in the SG, 0.2 M OxG and 0.4 M OxG. Dose-dependent apoptotic effects were evident from the TUNEL assay, and flow cytometry analysis of treated MDCK cells showed dose- and time-dependent effects. Our findings suggest that star fruit juice produces acute renal injury, not only through the obstructive effect of calcium oxalate crystals, but also by inducing apoptosis of renal epithelial cells, which may be caused by the levels of oxalate in the fruit.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Food and Chemical Toxicology - Volume 46, Issue 5, May 2008, Pages 1744–1752
نویسندگان
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