کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2589444 | 1562039 | 2016 | 9 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Effect of manganese and manganese plus noise on auditory function and cochlear structures
ترجمه فارسی عنوان
اثر منگنز و منگنز علاوه بر سر و صدا در عملکرد شنیداری و ساختار کوچهار
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
علوم محیط زیست
بهداشت، سم شناسی و جهش زایی
چکیده انگلیسی
The degenerative actions of Mn caused by persistent exposure to high atmospheric levels not only provokes irreversible damage to the CNS with symptoms comparable to that of Parkinson's disease but also may have deleterious consequences to other organs including the auditory system. The putative deleterious consequences of prolonged Mn overexposure on hearing, however, is confounded by the fact that chronically-exposed individuals often work in high noise environments where noise by itself is known to cause hearing loss. Thus, the question as to whether Mn alone is actually ototoxic and whether exposure to Mn when combined with noise increases the risk of hearing loss and cochlear pathology has never been examined. To examine whether noise effects Mn ototoxicity, we exposed rats to a moderate dose of Mn (10Â mg MnCl2/liter water) alone, a high level of noise (octave band noise, 8-16Â kHz, presented at 90Â dB SPL for 8Â h/d) alone or the combination of Mn plus noise and measured the changes in auditory function and the cochlear histopathologies. Results of these studies, based on various measures of hearing including histological examination of cochlear tissue suggest that noise alone produced significant hearing deficits whereas semi-chronic exposure to moderate levels of Mn in drinking water for 90Â days either in the presence or absence of noise had, at best, only a minor effect on hearing.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: NeuroToxicology - Volume 55, July 2016, Pages 65-73
Journal: NeuroToxicology - Volume 55, July 2016, Pages 65-73
نویسندگان
Vijaya Prakash Krishnan Muthaiah, Guang-Di Chen, Dalian Ding, Richard Salvi, Jerome A. Roth,