کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2589945 | 1131717 | 2010 | 4 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Early onset of neurological symptoms in fragile X premutation carriers exposed to neurotoxins
دانلود مقاله + سفارش ترجمه
دانلود مقاله ISI انگلیسی
رایگان برای ایرانیان
کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
علوم محیط زیست
بهداشت، سم شناسی و جهش زایی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Early onset of neurological symptoms in fragile X premutation carriers exposed to neurotoxins Early onset of neurological symptoms in fragile X premutation carriers exposed to neurotoxins](/preview/png/2589945.png)
چکیده انگلیسی
We present four cases of fragile X premutation carriers with early neurological symptoms, including symptoms consistent with multiple sclerosis (MS) and fragile X-associated tremor/ataxia syndrome (FXTAS). Each patient had significant exposure to one or more environmental neurotoxicants that have documented neurotoxicity (i.e. hexachlorocyclopentadiene or C56, Agent Orange, and 2,4- or 2,6-toluene diisocyanate and dichlormate). We hypothesize that premutation carriers are a vulnerable group to neurotoxins because elevated mRNA in the premutation can lead to early cell death and brain disease, leading to neuropsychiatric and neurological symptoms consistent with FXTAS.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: NeuroToxicology - Volume 31, Issue 4, August 2010, Pages 399–402
Journal: NeuroToxicology - Volume 31, Issue 4, August 2010, Pages 399–402
نویسندگان
Ripon Paul, Isaac N. Pessah, Louise Gane, Michele Ono, Paul J. Hagerman, James A. Brunberg, Flora Tassone, James A. Bourgeois, Patrick E. Adams, Danh V. Nguyen, Randi Hagerman,