کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2590235 | 1131730 | 2009 | 9 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Co-application of arsenic trioxide (As2O3) and cisplatin (CDDP) on human SY-5Y neuroblastoma cells has differential effects on the intracellular calcium concentration ([Ca2+]i) and cytotoxicity
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
علوم محیط زیست
بهداشت، سم شناسی و جهش زایی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Co-application of arsenic trioxide (As2O3) and cisplatin (CDDP) on human SY-5Y neuroblastoma cells has differential effects on the intracellular calcium concentration ([Ca2+]i) and cytotoxicity Co-application of arsenic trioxide (As2O3) and cisplatin (CDDP) on human SY-5Y neuroblastoma cells has differential effects on the intracellular calcium concentration ([Ca2+]i) and cytotoxicity](/preview/png/2590235.png)
چکیده انگلیسی
Application of As2O3 (1 μM) or CDDP (1 μM) increased [Ca2+]i. The largest elevation was observed when the basic [Ca2+]i concentration was low. Both, transient and sustained [Ca2+]i-increases were observed in response to a single application of As2O3 or CDDP. Sustained increase showed clear additive effects when both drugs were co-applied. The magnitude of the [Ca2+]i-increase depends on the order of application; the most pronounced effect occurred when the cells were preincubated with CDDP followed by a co-application with As2O3. The sustained [Ca2+]i elevations resulted in increased cytotoxicity and apoptosis. Therefore, co-treatment with CDDP and As2O3 may be a more effective anti-cancer therapy then either agent alone.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: NeuroToxicology - Volume 30, Issue 2, March 2009, Pages 194-202
Journal: NeuroToxicology - Volume 30, Issue 2, March 2009, Pages 194-202
نویسندگان
Dennis Alexander Günes, Ana-Maria Florea, Frank Splettstoesser, Dietrich Büsselberg,