Oxidative insults induce DJ-1 upregulation and redistribution: Implications for neuroprotection

Oxidative stress is implicated in the pathogenesis of central nervous system damage in neurodegenerative diseases as well as in normal aging. Parkinson's disease (PD) is one of the most common age-related neurodegenerative diseases caused by both environmental and inherited factors. DJ-1 mutations were recently identified in familial PD. The aim of this study was to elucidate the effects of the neurotoxins rotenone and 6-hydroxydopamine that lead to intracellul