کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2590368 1131739 2007 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Nicotine treatment regulates neuropeptide S system expression in the rat brain
موضوعات مرتبط
علوم زیستی و بیوفناوری علوم محیط زیست بهداشت، سم شناسی و جهش زایی
پیش نمایش صفحه اول مقاله
Nicotine treatment regulates neuropeptide S system expression in the rat brain
چکیده انگلیسی

Nicotine has marked effects on sleep, arousal and body weight. However, the neuronal mechanisms underlying these actions are not fully understood. Neuropeptide S (NPS) is a recently discovered neuropeptide regulating sleep, anxiety and feeding. Here, we examined the effect of acute and chronic nicotine treatment on the expression of NPS and its receptor (NPS-R) in the hypothalamus and brainstem of rats by using real-time PCR. Our results showed that chronic nicotine treatment induced significant changes in NPS and NPS-R expression whereas acute treatment exclusively induces a marked increase in the mRNA levels of NPS-R in the brainstem. Interestingly, we detected no changes in the expression levels of other set of genes present both in hypothalamus and brainstem. Overall, these data suggest that NPS system is specifically regulated by nicotine in the rat hypothalamus and brainstem.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: NeuroToxicology - Volume 28, Issue 6, November 2007, Pages 1129–1135
نویسندگان
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