کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2590727 1131767 2007 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Neuropsychiatric symptoms and past manganese exposure in a ferro-alloy plant
موضوعات مرتبط
علوم زیستی و بیوفناوری علوم محیط زیست بهداشت، سم شناسی و جهش زایی
پیش نمایش صفحه اول مقاله
Neuropsychiatric symptoms and past manganese exposure in a ferro-alloy plant
چکیده انگلیسی

IntroductionPsychiatric manifestations have been reported in cases of manganism, and mood disorders are often observed in manganese (Mn) exposed workers. We examined neuropsychiatric symptoms among formerly Mn-exposed workers 14 years after cessation of exposure.Materials and methodsA study was conducted in 1990 among workers from a ferro- and silico-Mn plant and unexposed working men referents from the same region in South-West Quebec. At follow-up in 2004, 77 former Mn-workers and 81 referents agreed to participate and responded to a neuropsychiatric symptom checklist, the Brief Symptom Inventory (BSI); scores were transformed into T-scores based on a normative population. Cumulated exposure indices (CEI) were computed for each former Mn-worker. Linear and logistic regression analyses were used.ResultsMean T-scores were significantly higher among former Mn-workers than referents on scales of Depression and Anxiety. Mean T-scores of psychological distress increased with the CEI tertiles, with significant associations for the scales Somatization, Depression, Anxiety and Hostility. Former Mn-workers in the two highest tertiles of CEI showed a higher risk for T-scores ≥63 for Hostility (OR, 7.5; 95% CI, 1.5–38.9), Depression (OR, 2.6; 95% CI, 1.1–8.4) and Anxiety (OR, 3.0; 95% CI, 1.1–8.4).ConclusionThese results suggest that past exposure to Mn may have lasting consequences on neuropsychiatric symptoms.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: NeuroToxicology - Volume 28, Issue 2, March 2007, Pages 290–297
نویسندگان
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