کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2595990 1562372 2011 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Exposure to 1-bromopropane causes degeneration of noradrenergic axons in the rat brain
موضوعات مرتبط
علوم زیستی و بیوفناوری علوم محیط زیست بهداشت، سم شناسی و جهش زایی
پیش نمایش صفحه اول مقاله
Exposure to 1-bromopropane causes degeneration of noradrenergic axons in the rat brain
چکیده انگلیسی

1-Bromopropane (1-BP) has been used as an alternative to ozone-depleting solvents. Previous studies showed that 1-BP is neurotoxic in animals and humans. In humans, exposure to 1-BP caused various neurological and neurobehavioral symptoms or signs including depressive or irritated mood. However, the neurobiological changes underlying the depressive symptoms induced by 1-BP remain to be determined. The depressive symptoms are thought to be associated with degeneration of axons containing noradrenaline and serotonin. Based on this hypothesis, the present study examined the effects of repeated exposure to 1-BP on serotonergic and noradrenergic axons. Exposure to 1-BP induced dose-dependent decreases in the density of noradrenergic axons in the rat prefrontal cortex, but no apparent change in the density of serotonergic axons. The results suggest that depressive symptoms in workers exposed to 1-BP are due, at least in part, to the degeneration of noradrenergic axons in the brain.


► 1-Bromopropane degenerates noradrenergic axons in medial prefrontal cortex.
► 1-Bromopropane degenerates noradrenergic axons in amygdala.
► The degeneration of noradrenergic axons occurs in a dose-dependent manner.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Toxicology - Volume 285, Issues 1–2, 11 July 2011, Pages 67–71
نویسندگان
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