کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2597234 1132574 2008 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Ameliorative action of cyanobacterial phycoerythrin on CCl4-induced toxicity in rats
موضوعات مرتبط
علوم زیستی و بیوفناوری علوم محیط زیست بهداشت، سم شناسی و جهش زایی
پیش نمایش صفحه اول مقاله
Ameliorative action of cyanobacterial phycoerythrin on CCl4-induced toxicity in rats
چکیده انگلیسی

Carbon tetrachloride (CCl4) is largely used as solvent in chemical industries. Carbon tetrachloride is also well known for hepatic and renal toxic actions. The in vivo metabolism of carbon tetrachloride to trichloromethyl (CCl3) and peroxy trichloromethyl (OOCCl3) radicals has been extensively reported to cause acute liver damage like cirrhosis, steatosis and necrosis. We have evaluated protective action of purified cyanobacterial phycoerythrin (C-PE) on carbon tetrachloride-induced hepatic and renal toxicity in male rats. Rats were orally treated with 25 and 50 mg/kg BW of C-PE along with CCl4 (50% CCl4, 0.5 ml/kg BW, intraperitoneally) for 28 consecutive days. Results demonstrated that C-PE dose-responsively ameliorates CCl4-toxicity by significantly decreasing (P < 0.05) organs weight, aminotransferases, alkaline phosphatase, glucose, lipid profile, creatinine, uric acid and malondialdehyde (MDA) concentrations with rise in body weight, food intake, hemoglobin, protein, bilirubin and FRAP values. Neither C-PE nor CCl4 influenced on serum minerals. Hepatic and renal tissues showed significant decline (P < 0.05) in malondialdehyde, lipid hydroperoxides and conjugated dienes with rise in SOD, catalase, GPx, GSH, vitamin-E and vitamin-C levels. Presently observed pharmacological effect on CCl4 toxicity were from tetrapyrrole molecule and to some extent bilirubin biotransformations, as well as metabolic (dietary protein) actions of C-PE.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Toxicology - Volume 248, Issue 1, 3 June 2008, Pages 59–65
نویسندگان
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