کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2597328 1132576 2008 10 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
The potential protective role of alpha-lipoic acid against acetaminophen-induced hepatic and renal damage
موضوعات مرتبط
علوم زیستی و بیوفناوری علوم محیط زیست بهداشت، سم شناسی و جهش زایی
پیش نمایش صفحه اول مقاله
The potential protective role of alpha-lipoic acid against acetaminophen-induced hepatic and renal damage
چکیده انگلیسی

The potential protective role of alpha-lipoic acid (α-LA) in acetaminophen (APAP)-induced hepatotoxicity and nephrotoxicity was investigated in rats. Pretreatment of rats with α-LA (100 mg/kg) orally protected markedly against hepatotoxicity and nephrotoxicity induced by an acute oral toxic dose of APAP (2.5 g/kg) as assessed by biochemical measurements and by histopathological examination. None of α-LA pretreated animals died by the acute toxic dose of APAP. Concomitantly, APAP-induced profound elevation of nitric oxide (NO) production and oxidative stress, as evidenced by increasing of lipid peroxidation level, reducing of glutathione peroxidase (GSH-Px) activity and depleting of intracellular reduced glutathione (GSH) level in liver and kidney, were suppressed by pretreatment with α-LA. Similarly, daily treatment of rats with a smaller dose of α-LA (25 mg/kg) concurrently with a smaller toxic dose of APAP (750 mg/kg) for 1 week protected against APAP-induced hepatotoxicity and nephrotoxicity. This treatment also completely prevented APAP-induced mortality and markedly inhibited APAP-induced NO overproduction and oxidative stress in hepatic and renal tissues. These results provide evidence that inhibition of NO overproduction and maintenance of intracellular antioxidant status may play a pivotal role in the protective effects of α-LA against APAP-induced hepatic and renal damage.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Toxicology - Volume 243, Issue 3, 20 January 2008, Pages 261–270
نویسندگان
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