کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2597597 1132592 2007 9 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Sodium nitroprusside and l-arginine attenuates ferric nitrilotriacetate-induced oxidative renal injury in rats
موضوعات مرتبط
علوم زیستی و بیوفناوری علوم محیط زیست بهداشت، سم شناسی و جهش زایی
پیش نمایش صفحه اول مقاله
Sodium nitroprusside and l-arginine attenuates ferric nitrilotriacetate-induced oxidative renal injury in rats
چکیده انگلیسی

The role of nitric oxide (NO) in acute renal failure (ARF) is debatable. In the present study, we investigated the effect of acute administration of NO donor, Sodium nitroprusside (SNP), l-Arginine (l-Arg) and NO synthase inhibitor, N(omega)-l-arginine methyl ester (l-NAME) in Fe-NTA induced renal toxicity. Rats were pretreated with SNP (2.5 mg/kg i.p), l-Arg (125 mg/kg, i.p.) and l-NAME (10 mg/kg, i.p.) prior to administration of Fe-NTA (8 mg iron/kg body weight, i.p.) to determine the urea and creatinine levels along with biochemical analysis of oxidative stress. Fe-NTA administration markedly increased the BUN and serum creatinine level which was coupled with a marked lipid peroxidation, decreased levels of reduced glutathione and total nitric oxide levels of rat kidneys coupled with significant morphological alterations. It also resulted in the significant increase in tumor necrosis factor-α (TNF-α) in serum. Concomitant treatment with SNP and l-Arg significantly reduced the serum creatinine and BUN levels, reduced lipid peroxidation in a significant manner, restored levels of reduced glutathione, increased total nitric oxide levels and restored the normal morphology. Pretreatment with SNP and l-Arg attenuated the levels of TNF-α in serum in a significant manner. Prior administration of l-NAME reversed the protective effects produced by SNP and l-Arg. Present findings strongly suggest that nitric oxide plays a significant role in the pathophysiology of iron-induced renal failure and administration of NO donors can be valuable in the treatment of ARF.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Toxicology - Volume 232, Issue 3, 11 April 2007, Pages 183–191
نویسندگان
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