کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2597827 1562424 2007 9 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
The role of ROS in microcystin-LR-induced hepatocyte apoptosis and liver injury in mice
موضوعات مرتبط
علوم زیستی و بیوفناوری علوم محیط زیست بهداشت، سم شناسی و جهش زایی
پیش نمایش صفحه اول مقاله
The role of ROS in microcystin-LR-induced hepatocyte apoptosis and liver injury in mice
چکیده انگلیسی

Microcystin-LR (MC-LR) produced by cyanobacteria in diverse water systems is a potent specific hepatotoxin and has been documented to induce hepatocyte apoptosis and liver injury; however, the mechanisms have not been fully elucidated. In the present study, we investigated whether MC-LR stimulated ROS generation in the liver of mice and the role of ROS in the pathogenesis of MC-LR-induced liver injury in vivo. MC-LR treatment (60 μg/kg of body weight) for 12 h prompted large amount of ROS generation in mice liver, upregulated the expression of Bax and Bid, caused the mitochondrial membrane potential (MMP) loss and hepatocyte apoptosis as well as liver injury. While pretreatment with antioxidants, oral administration of vitamin C (250 mg/kg of body weight, dissolved in double distill water) and vitamin E (200 mg/kg of body weight, dissolved in corn oil) per day for 3 days continually, significantly reduced the generation of ROS and effectively inhibited the MC-LR-induced hepatocyte apoptosis and liver injury, suggesting that ROS played a critical role in MC-LR-induced hepatocyte apoptosis and liver injury. The protective effect of vitamin C and E also suggested the potential interest in the clinical treatment of MC-LR-induced liver injury and hepatotoxicity.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Toxicology - Volume 232, Issues 1–2, 22 March 2007, Pages 15–23
نویسندگان
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