کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2607872 1562788 2010 4 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Update on transplantation tolerance
ترجمه فارسی عنوان
به روز رسانی در تحمل عمل پیوند
کلمات کلیدی
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی بیهوشی و پزشکی درد
چکیده انگلیسی

SummaryThe induction of transplantation tolerance has become a major goal, because modern immunosuppressive therapy has not improved chronic rejection rates, and is associated with significant side effects. This article aims to explain the principles of immunological tolerance. Mechanisms of central tolerance involve deletion of self-reactive T cells. Mechanisms of peripheral tolerance are reviewed and also the identification of a subset of regulatory T cells which are characterised by the expression of the transcription factor FoxP3.Interesting recent insights on the role of the ‘anti-inflammatory’ cytokine transforming growth factor β which can ultimately lead to the generation of inhibitory Tregs or inflammatory Th17 cells (CD4 helper T cells which secrete the pro-inflammatory cytokine IL17) are discussed.There are many ways to induce experimental tolerance in animals, however these are difficult to translate tolerance into the clinical context. In addition, standard immunosuppressive agents are calcineurin inhibitors which block T cell activation and IL-2 production. These drugs not only inhibit the activation of effector T cells, but also Tregs, therefore inhibiting Treg driven tolerance induction. Other classes of immunosuppressive drugs should be introduced into the clinic to allow for the possibility of tolerance induction. Strategies to modulate immune responses following transplantation and their potential risks are discussed.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Current Anaesthesia & Critical Care - Volume 21, Issues 5–6, October–December 2010, Pages 229–232
نویسندگان
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