The effects of Lyprinol® on delayed onset muscle soreness and muscle damage in well trained athletes: A double-blind randomised controlled trial

SummaryObjectivesThe aim of the study was to determine if Lyprinol® is effective in reducing pain, indicators of inflammation and muscle damage, and in turn improving performance in well trained athletes suffering from delayed onset muscle soreness (DOMS).DesignA double blind randomised placebo controlled trial.SettingTwenty well trained male volunteers, matched by VO2 max were randomly assigned to consume 200 mg of Lyprinol® or an indistinguishable placebo daily for 8 weeks prior to a downhill treadmill running episode designed to induce DOMS.Main outcome measuresPerformance measures (Kin-Com, counter movement and squat jump), pain assessments (visual analogue scale, algometer) and blood analyses (Interleukin-1, Interleukin-6, Interleukin-10, tumour necrosis factor-α, C-reactive protein, myoglobin, creatine kinase) were assessed at 7 time points over 5 days (pre, post, 4, 24, 48, 72 and 96 h after the downhill run).ResultsNo statistically significant differences were identified in any parameters between the active and placebo groups at any time point.ConclusionAfter 2 months ingestion of Lyprinol® at the currently recommended dosage (200 mg/day) and a demanding eccentric exercise intervention, Lyprinol® did not convincingly affect DOMS and indicators of muscle damage.