Observations on entanglement, non-locality and ultra-high dilutions

• Progress since 1994 of the scientific basis of the manufacture of UHD and their working.
• Concepts of entanglement, non-locality and their application in ultra-high dilution research.
• A period of reflection and consolidation in ultra-high dilution research.
• Call for identifying models with measurable predictors that go beyond metaphorical descriptors.

IntroductionFundamental research into the scientific basis of the manufacture of ultra-high dilutions and their working in applications has evolved over the past twenty years since our last critical analysis of the field was published in 1994 [1]. New contenders from the realm of physics (entanglement, non-locality) have entered the scene. The vast majority within the community of the application of ultra-high dilutions are not physicists. This paper attempts to elucidate the concepts of entanglement, non-locality and their application in ultra-high dilution research (UHD).MethodA selected study on the activity of fundamental research into UHD is performed to gain insight into trends of development activity of fundamental research in this area. In an attempt to nurture further development of theoretical models in fundamental research in UHD, an attempt is made to made recent theoretical concepts more accessible to the larger community including practitioners, policy makers and beneficiaries of UHD.ResultsFundamental research in UHD had a period of prolific activity and recognition at the turn of the millennium until about ten years ago. Since then, research output as well as its recognition receded sharply suggesting that a period of reflection and consolidation may be in progress.ConclusionThe study and the knowledge gained from more recent theoretical models in UHD and entanglement suggest that there may be some benefit in stocktaking of what we really know about the fundamental workings of UHD as well as identifying or developing models that include measurable predictors that go beyond metaphorical descriptors.