کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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2651847 | 1139546 | 2011 | 9 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: Meta-analysis of long-term outcomes of drug-eluting stent implantations for chronic total coronary occlusions Meta-analysis of long-term outcomes of drug-eluting stent implantations for chronic total coronary occlusions](/preview/png/2651847.png)
BackgroundIn the treatment of chronic total occlusions (CTOs), some uncertainty exists regarding the effect of drug-eluting stents (DESs) compared with the effects of bare mental stents (BMSs). We reviewed outcomes of DES vs. BMS implantation for CTO lesions, to evaluate the risk-benefit ratio of DES implantation.MethodsRelevant studies of long-term clinical outcomes or angiographic outcomes of both BMS and DES implantation were examined. The primary endpoint comprised major adverse cardiovascular events (MACEs), including all-cause deaths, myocardial infarctions (MIs), and target lesion revascularizations (TLRs). A fixed-effect model and random-effect model were used to analyze the pooling results.ResultsTen studies were included according to the selection criteria. Eight were nonrandomized controlled trials, and two consisted of a randomized controlled comparison between DES and BMS implantation. No significant difference was evident for in-hospital MACE rates between the two groups (odds ratio [OR], 1.07; 95% confidence interval [CI], .53 to 2.13), but the long-term MACE rates in the DES group were significantly lower than in the BMS group (OR, .22; 95% CI, .13 to .38; P < .00001). The rates of stent restenosis and reocclusions were also significantly lower in the DES group (OR, .14; 95% CI, .09 to .20; and OR, .23; 95% CI, .12 to .41, respectively).ConclusionImplantation of the DES improves long-term angiographic and clinical outcomes compared with BMS in the treatment of CTO lesions.
Journal: Heart & Lung: The Journal of Acute and Critical Care - Volume 40, Issue 3, May–June 2011, Pages e32–e40