کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2683213 1142622 2010 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Relation of ghrelin, leptin and inflammatory markers to nutritional status in active pulmonary tuberculosis
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی مراقبت های ویژه و مراقبتهای ویژه پزشکی
پیش نمایش صفحه اول مقاله
Relation of ghrelin, leptin and inflammatory markers to nutritional status in active pulmonary tuberculosis
چکیده انگلیسی

SummaryBackgrounds & aimsMalnutrition is a prominent feature of tuberculosis. Little is known about the role of the appetite-related hormones, ghrelin and leptin, in malnutrition in tuberculosis. This study was undertaken to determine whether ghrelin and leptin contribute to malnutrition in active pulmonary tuberculosis.MethodsNutritional parameters and plasma levels of ghrelin, leptin, and inflammatory cytokines were measured before treatment and after clinical improvement following anti-tuberculosis chemotherapy in 23 tuberculosis subjects and 23 healthy controls prospectively. Patients were divided into well-nourished (n = 15) and malnourished (n = 8) groups.ResultsGhrelin but not leptin levels were significantly lower in the malnourished tuberculosis group than in the well-nourished tuberculosis group [44.0 (43.0–54.0) vs. 122 (108–158) pg/mL; p < 0.05]. Malnutrition score was negatively correlated to ghrelin (ρ = −0.76, p < 0.01) but not to leptin levels. TNF-α and IL-6 levels were significantly higher in the malnourished tuberculosis group than in the well-nourished tuberculosis group and controls. Plasma levels of ghrelin tended to decrease as inflammatory cytokines increased before treatment.ConclusionsDecreased plasma ghrelin levels, in addition to increased plasma inflammatory cytokine levels, may be associated with malnutrition in active pulmonary tuberculosis.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Clinical Nutrition - Volume 29, Issue 4, August 2010, Pages 512–518
نویسندگان
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