کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2684008 1142711 2013 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Long-term olive oil-based parenteral nutrition sustains innate immune function in home patients without active underlying disease
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی مراقبت های ویژه و مراقبتهای ویژه پزشکی
پیش نمایش صفحه اول مقاله
Long-term olive oil-based parenteral nutrition sustains innate immune function in home patients without active underlying disease
چکیده انگلیسی

SummaryBackground & aimsIt remains unclear whether impaired host defenses contribute to the increased risk for infectious complications seen in patients on home parenteral nutrition (HPN). The aim of this study was to compare the innate immune function of patients on olive oil-based HPN with that of healthy controls.MethodsInnate immune functions and (anti-)oxidant balance were studied in 20 patients on olive oil-based HPN without an active underlying immune-mediated disease (Clinoleic®, ≥6 months; >3 times/week), and 21 age- and sex-matched healthy controls.ResultsNeutrophils of patients and controls had a similar capacity to eliminate Streptococcus pneumoniae. Also, levels of activation markers (CD66b, CD11b, CD62L) in granulocytes and monocytes, phorbol ester- and zymosan-induced neutrophil oxygen radical production were not different between patients and controls. No differences in (anti-)oxidant status were found, except for higher concentrations of oxidized glutathione and lower plasma selenium and vitamin C in patients compared to controls.ConclusionCompromised innate immune function does not seem to explain the increased risk for infectious complications in HPN patients using olive oil-based lipid emulsions.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Clinical Nutrition - Volume 32, Issue 4, August 2013, Pages 643–649
نویسندگان
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