کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2684187 1142730 2011 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Nutrient intake and serum level of gamma-glutamyltransferase, MCP-1 and homocysteine in early stages of heart failure
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی مراقبت های ویژه و مراقبتهای ویژه پزشکی
پیش نمایش صفحه اول مقاله
Nutrient intake and serum level of gamma-glutamyltransferase, MCP-1 and homocysteine in early stages of heart failure
چکیده انگلیسی

SummaryBackground & aimsDietary quality probably may impact heart failure outcomes. The aim of the study was to determine the potential effects of nutrient intake on homocysteine, MCP-1 and GGT levels in patients with heart failure.MethodsThe study group comprised 55 patients with diagnosed HF with coronary artery disease origin, below 65y, with NYHA class I/II. The patients had received standard treatment. The control comprised 55 patients with mild hyperlipidemia, not treated. Diet was evaluated on the basis of a dietary questionnaire and a 24-h dietary recall. The serum lipid profile, folic acid, homocysteine, GGT and MCP-1 were determined.ResultsIn the HF group significantly higher concentration of homocysteine (32%), MCP-1 (58%) and GGT (100%) are found as compared to the control group (p < 0.00001). Patients with HF had greater cholesterol consumption, with less folates, vitamin C and dietary fiber as compared to the control group (p < 0.05).ConclusionHigh consumption of total fat and dietary cholesterol accompanied by a low folate, antioxidant vitamin, a special vitamin C and dietary fiber intake, contributes to elevated Hcy, GGT and MCP-1 levels and in consequence, could lead to intense inflammatory process and atherosclerosis in HF patients.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Clinical Nutrition - Volume 30, Issue 1, February 2011, Pages 73–78
نویسندگان
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