کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2684549 1142756 2006 12 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Oligosaccharides isolated from goat milk reduce intestinal inflammation in a rat model of dextran sodium sulfate-induced colitis
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی مراقبت های ویژه و مراقبتهای ویژه پزشکی
پیش نمایش صفحه اول مقاله
Oligosaccharides isolated from goat milk reduce intestinal inflammation in a rat model of dextran sodium sulfate-induced colitis
چکیده انگلیسی

SummaryBackground and aimsThere is increased interest in the study of manipulation of the flora with pro- and prebiotics regarding inflammatory bowel disease. The aim of this work was to evaluate the effect of oligosaccharides from goat milk in a rat model of dextran sodium sulfate- (DSS-) induced colitis.MethodsTwenty rats were fed the same diet but with different sources of fiber (5% of the diet): cellulose or a mixture of goat's milk oligosaccharides (GMO) and cellulose. DSS treatment was used to induce a colonic inflammation. Several clinical and inflammatory parameters, as well as intestinal micorbiota and gene expression by DNA microarray technology, were evaluated.ResultsDSS induced a decrease in body weight which was not observed in rats fed the GMO (decrease of 21±11% in control rats vs increase of 5.2±8.6 in GMO rats, P<0.05P<0.05). DSS also caused an acute colonic inflammatory process which was weaker in rats fed the GMO, as shown by colon myeloperoxidase activity (0.53±0.16 vs 0.14±0.07 U/mg of protein, P<0.05P<0.05), as well as clinical symptoms measured by a scoring system (1.25±1.14 vs 0.4±0.07, P<0.05P<0.05). GMO rats also showed less severe colonic lesions and a more favorable intestinal microbiota. The expression of genes involved in intestinal function, such as mucine-3, was down-regulated in DSS-control rats but returned to normal values in GMO rats.ConclusionGMO reduce intestinal inflammation and contribute to the recovery of damaged colonic mucosa.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Clinical Nutrition - Volume 25, Issue 3, June 2006, Pages 477–488
نویسندگان
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