کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2686799 1142984 2013 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Berberine improves reproductive features in obese Caucasian women with polycystic ovary syndrome independently of changes of insulin sensitivity
ترجمه فارسی عنوان
Berberine ویژگی های باروری در زنان چاق قفقازی با سندرم تخمدان پلی کیستیک را به طور مستقل از تغییرات حساسیت به انسولین بهبود می بخشد
کلمات کلیدی
بربرین؛ PCOS؛ مقاومت به انسولین؛ FAI؛ تستوسترون؛ شاخص توده بدنی
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی مراقبت های ویژه و مراقبتهای ویژه پزشکی
چکیده انگلیسی

Background and aimsBerberine (BBR) is an isoquinoline derivative alkaloid isolated from Rhizoma Coptidis traditionally used as anti diarrheic and, more recently, as hypolipidemic and insulin sensitizer agent. Thus, BBR could represent a potential therapeutic option for patients with polycystic ovary syndrome (PCOS). The aim of this study was to evaluate the clinical, metabolic and hormonal effects of BBR in PCOS women.MethodsFifty oligoamenorrheic PCOS obese women and 50 age and Body Mass Index (BMI) matched healthy controls were enrolled. PCOS women received BBR treatment (500 mg, 2 times daily) for 6 months. Clinical and biochemical parameters were assessed before and after the treatment period.ResultsTotal testosterone (p < 0.01), free androgen index (p < 0.01), androstenedione (p < 0.01), sex hormone binding globulin (p < 0.01), progesterone (p < 0.01), total cholesterol (p = 0.01), low density lipoprotein cholesterol (p < 0.01), triglycerides (p < 0.01), area under the curve of insulin (p < 0.01), menses frequency (p < 0.01) and Waist Circumference (p = 0.04) significantly (p < 0.05) improved after BBR treatment. No correlation was found between variations of insulin sensitivity and hormonal changes.ConclusionsBBR improves clinical, metabolic and reproductive features in PCOS women. Its mechanism of actions need to be elucidated in further studies.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: e-SPEN Journal - Volume 8, Issue 5, October 2013, Pages e200–e204
نویسندگان
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