کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2687284 | 1143007 | 2010 | 6 صفحه PDF | دانلود رایگان |

SummaryBackground & aimsIn patients with recent hip fracture, reduced serum IGF-I in relation to protein undernutrition is frequent. Elevation of circulating IGF-I in response to a daily oral supplement of 20 g of casein was observed after 6 months. This study determined if the response to casein as compared to whey protein can be observed as early as after one week.Methods45 Women were randomized after recent hip fracture in 3 groups receiving a preparation of 20 g of casein, an isocaloric supplement of 20 g of whey protein or an isocaloric supplement of 15 g of whey protein combined with 5 g of essential amino acids (a.a.).ResultsA similar significant elevation of serum IGF-I was already observed after 7 days for casein (+37.3 μg/L), whey (+29.4) and for whey + a.a. (+34.3). From day 7–28, no further significant rise in IGF-I was recorded.ConclusionAfter one week of protein supplementation, the percent increase of IGF-I was of similar magnitude to that previously observed after 6 months of protein supplementation. It suggests that in hip fracture patients, long-term effects of various protein preparations on IGF-I could be predicted from changes observed as early as 7 days after the onset of supplementation.
Journal: Clinical Nutrition - Volume 29, Issue 1, February 2010, Pages 78–83