کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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2687685 | 1143035 | 2008 | 6 صفحه PDF | دانلود رایگان |

SummaryBackground & aimsMeasurement of serum iron increase after ingestion of a meal could be an efficient method of comparing post-prandial iron absorption between groups of individuals. We determined whether the rise in post-prandial serum iron is increased in fully treated patients with hereditary haemochromatosis (HFE C282Y+/+; HH) compared to iron deficiency anaemia (IDA), iron-replete heterozygous subjects (HFE C282Y+/−) and iron-replete controls (HFE C282Y−/−).MethodsSerum iron increase was measured over 4 h after a meal containing 13.1 mg non-haem iron.ResultsPost-prandial increase in serum iron was similar in treated HH versus IDA (P = 0.54), but greater than control subjects (P < 0.0001). In five HH patients, using 58Fe as a tracer, the rate of iron absorption was increased (P < 0.05) and serum non-transferrin bound iron showed a tendency to increase (P = 0.06). Serum iron curves did not differ for heterozygous subjects and controls (P = 0.65).ConclusionsUsing the serum iron method we found a comparable increase in post-prandial iron absorption in treated HH and IDA compared with controls. While post-prandial iron absorption in the group heterozygous for the C282Y mutation was modestly increased relative to controls, this difference was not statistically significant.
Journal: Clinical Nutrition - Volume 27, Issue 2, April 2008, Pages 258–263