کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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2691491 | 1143355 | 2014 | 8 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: In vitro modulation of TH1 and TH2 cytokine expression by edible tuber of Dioscorea alata and study of correlation patterns of the cytokine expression In vitro modulation of TH1 and TH2 cytokine expression by edible tuber of Dioscorea alata and study of correlation patterns of the cytokine expression](/preview/png/2691491.png)
The underground tuber of Dioscorea alata is a palatable food and is also claimed to have therapeutic effects. Various groups of researchers demonstrated different activities of this tuber such as antioxidant, hepatoprotective, anti-ulcer and anti-diabetic activities. Therefore, the aim of the present study was to evaluate the immunomodulatory potentialities of 70% hydro-methanolic extract of D. alata underground tubers by investigating different parameters like the expression of interferon gamma (IFN-γ), interleukin (IL)-2, IL-4 and IL-10, in addition to its effect on the proliferation of murine splenic T-lymphocytes in vitro. Results demonstrated that D. alata can actively polarize the TH0 lymphocyte population towards the expression of TH1 immune response by up-regulating the IFN-γ and IL-2 expression and down-regulating the IL-4 and IL-10 expression. The tuber extract also proved to possess mitogenic activity as evidenced by the proliferation of lymphocytes in vitro.
Journal: Food Science and Human Wellness - Volume 3, Issue 1, March 2014, Pages 1–8