کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2693340 1143524 2010 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Tear film dynamics and lipid layer characteristics—Effect of age and gender
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی چشم پزشکی
پیش نمایش صفحه اول مقاله
Tear film dynamics and lipid layer characteristics—Effect of age and gender
چکیده انگلیسی

PurposeDry eye disease is significantly more prevalent in older subjects and among them more marked in women than men. Further, it is established that the tear film dynamics of dry eye sufferers is different to that of normal. It is therefore postulated that the greater prevalence of dry eye problems with advancing age is at least in part related to poorer tear film dynamics.MethodsTear film dynamics (non-invasive break up time) and lipid characteristics (lipid layer thickness and contamination) were assessed using the Tearscope lighting system.Results160 Subjects less than 45 years old and 58 subjects aged 45 years or more formed the study populations. The tear film stability was mostly influenced by age; the break up time was statistically significantly shorter for the older age group (p < 0.001). The lipid layer was also significantly thinner (p = 0.013) for the subjects aged 45 years or older with a very marked synergic effect of age and gender. The lipid layer of older women was significantly thinner and more contaminated than that of younger women (p = 0.002 and <0.001) and of older men (p = 0.034 and 0.004).ConclusionsAging of the tear film is characterised by its destabilisation associated with significant changes in the tear lipid layer producing less protection from evaporation in the older population; the observed changes are more marked in women than in men. The findings have significant implications for the management of presbyopic dry eye sufferers, for whom decreasing evaporative problems is essential.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Contact Lens and Anterior Eye - Volume 33, Issue 4, August 2010, Pages 176–182
نویسندگان
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