کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2701891 1144481 2008 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Insulin resistance, physical fitness, body composition and leptin concentration in 7–8 year-old children
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی ارتوپدی، پزشکی ورزشی و توانبخشی
پیش نمایش صفحه اول مقاله
Insulin resistance, physical fitness, body composition and leptin concentration in 7–8 year-old children
چکیده انگلیسی

SummaryThe aim of this study was to investigate the association between insulin resistance and physical fitness, leptin concentration, body composition and family history for diabetes in non-selected young children. Physical fitness, fasting plasma glucose, insulin and leptin concentrations, anthropometric characteristics and medical history were available in two hundred and fifty-seven 7-year-old Dutch children. Correlations with the homeostasis model assessment (HOMA) index for insulin resistance were studied. A multiple regression model was calculated for HOMA. The differences between children with or without a family history for diabetes were not significant. Boys scored higher on glucose concentration and aerobic fitness and lower on sum of skin folds and leptin concentration (p < .05). After adjustment for sum of skin folds, HOMA was significantly associated with leptin in both genders (boys r = .184 p = .031; girls r = .430 p = .000). The association between physical fitness and HOMA was mediated by sum of skin folds. The associations were stronger in girls than in boys. In the regression model (R2 = .205) the leptin concentration was the only significant predictor for HOMA. The influence of family history for diabetes on insulin resistance is shown as a trend at this age. Our findings suggest that plasma leptin concentration is independently associated with the development of insulin resistance in a non-selected prepubertal population. The association of physical fitness with insulin resistance seems to be mediated by the sum of skin folds.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Science and Medicine in Sport - Volume 11, Issue 2, April 2008, Pages 132–138
نویسندگان
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