کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2711869 1145056 2008 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Cortical Atrophy and White Matter Hyperintensities in HIV: The Hawaii Aging with HIV Cohort Study
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی مغز و اعصاب بالینی
پیش نمایش صفحه اول مقاله
Cortical Atrophy and White Matter Hyperintensities in HIV: The Hawaii Aging with HIV Cohort Study
چکیده انگلیسی

BackgroundAs many human immunodeficiency virus (HIV)-seropositive individuals are now living longer after infection because of highly active antiretroviral therapy, aging-related manifestations of cerebral small-vessel ischemic vascular disease, such as brain white matter hyperintensities (WMHs), are becoming increasingly important in this population.GoalsThis study was designed to determine the relationship between WMHs and cortical volumes in HIV-seropositive individuals.Materials and MethodsVoxel-based morphometry was used to compare cortical volumes among 62 HIV-seropositive individuals participating in the Hawaii Aging with HIV Cohort Study, 30 with moderate WMHs and 32 with minimal or no WMHs.ResultsPresence of moderate WMHs was associated with decreased cortical volumes in the frontal lobes bilaterally.ConclusionThese findings suggest that age-related WMHs are associated with reduced frontal gray matter volumes in HIV-seropositive individuals, supporting the hypothesis that the frontal lobes may have greater susceptibility to the effects of small-vessel ischemic vascular disease.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Stroke and Cerebrovascular Diseases - Volume 17, Issue 4, July–August 2008, Pages 212–217
نویسندگان
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