کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2722800 1566720 2016 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Trends in Opioid Dosing Among Washington State Medicaid Patients Before and After Opioid Dosing Guideline Implementation
ترجمه فارسی عنوان
روند دوزهای اپيوئيد در بيماران واجد شرايط دريافت کننده واکسيناسيون قبل و بعد از اجرای دستورالعمل دوزهای اپيوئيد
کلمات کلیدی
درد مزمن؛ دوز معادل مورفین؛ اپیویید ایمنی؛ سیاست
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی عصب شناسی
چکیده انگلیسی


• In 2007, an Opioid Dosing Guideline was released in Washington State which discouraged high-dose opioid use.
• We report on opioid dosing in the WA Medicaid fee-for-service population N=273,000 from 4/1/06 to 12/31/10.
• Prescriptions for opioids among WA Medicaid adults peaked in 2009.
• Median opioid dose was unchanged from 2006 to 2010 at 37.5mg MED, but doses at 75th, 90th, 95th, and 99th percentiles declined.
• This indicates that high-dose opioid therapy can be reduced without altering median opioid dose in a Medicaid population.

By 2007, opioid-related mortality in Washington state (WA) was 50% higher than the national average, with Medicaid patients showing nearly 6 times the mortality of commercially-insured patients. In 2007, the WA Interagency Guideline on Opioid Dosing for Chronic Non-cancer Pain was released, which recommended caution in prescribing >120 mg morphine-equivalent dose per day for patients not showing clinically meaningful improvement in pain and function. We report on opioid dosing in the WA Medicaid fee-for-service population for 273,200 adults with a paid claim for an opioid prescription between April 1, 2006 and December 31, 2010. Linear regression was used to test for trends in dosing over that time period, with quarter-year as the independent variable and median daily dose as the dependent variable. Prescription opioid use among WA Medicaid adults peaked in 2009, as evidenced by the unique number of opioid users (105,232), the total number of prescriptions (556,712), and the total person-years of prescription opioid use (29,442). Median opioid dose was unchanged from 2006 to 2010 at 37.5 mg morphine-equivalent dose, but doses at the 75th, 90th, 95th, and 99th percentiles declined significantly (P < .001). These results suggest that opioid treatment guidelines with dosing guidance may be able to reduce high-dose opioid use without affecting the median dose used.PerspectiveSome fear that opioid dosing guidelines might restrict access to opioid therapy for patients who could benefit. However, there is evidence that high-dose opioid therapy entails significant risks without demonstrated benefit. These findings indicate that high-dose opioid therapy can be reduced without altering median opioid dose in a Medicaid population.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: The Journal of Pain - Volume 17, Issue 5, May 2016, Pages 561–568
نویسندگان
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