کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2722869 1566725 2016 13 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Clinically Effective Treatment of Fibromyalgia Pain With High-Definition Transcranial Direct Current Stimulation: Phase II Open-Label Dose Optimization
ترجمه فارسی عنوان
درمان موثر و بالینی درد فیبرومیالژیا با تحریک جریان مستقیم ترانس کرانیال با کیفیت بالا: بهینه سازی فاز دوم دوز برچسب باز
کلمات کلیدی
فیبرومیالژی؛ درد؛ تحریک مغزی غیر انسدادی؛ تحریک جریان مستقیم ترانس کرانانی با کیفیت بالا؛ قشر حرکتی
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی عصب شناسی
چکیده انگلیسی


• High-definition transcranial direct current stimulation (HD-tDCS) provides targeted, specific, and tolerable subthreshold brain stimulation.
• We present an optimized protocol option for the treatment of fibromyalgia (FM) pain.
• We report a clinically significant benefit of a 50% pain reduction in patients with FM.
• We estimate ∼15 HD-tDCS sessions to reach clinically meaningful outcomes.

Despite promising preliminary results in treating fibromyalgia (FM) pain, no neuromodulation technique has been adopted in clinical practice because of limited efficacy, low response rate, or poor tolerability. This phase II open-label trial aims to define a methodology for a clinically effective treatment of pain in FM by establishing treatment protocols and screening procedures to maximize efficacy and response rate. High-definition transcranial direct current stimulation (HD-tDCS) provides targeted subthreshold brain stimulation, combining tolerability with specificity. We aimed to establish the number of HD-tDCS sessions required to achieve a 50% FM pain reduction, and to characterize the biometrics of the response, including brain network activation pain scores of contact heat-evoked potentials. We report a clinically significant benefit of a 50% pain reduction in half (n = 7) of the patients (N = 14), with responders and nonresponders alike benefiting from a cumulative effect of treatment, reflected in significant pain reduction (P = .035) as well as improved quality of life (P = .001) over time. We also report an aggregate 6-week response rate of 50% of patients and estimate 15 as the median number of HD-tDCS sessions to reach clinically meaningful outcomes. The methodology for a pivotal FM neuromodulation clinical trial with individualized treatment is thus supported.Online RegistrationRegistered in Clinicaltrials.gov under registry number NCT01842009.PerspectiveIn this article, an optimized protocol for the treatment of fibromyalgia pain with targeted subthreshold brain stimulation using high-definition transcranial direct current stimulation is outlined.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: The Journal of Pain - Volume 17, Issue 1, January 2016, Pages 14–26
نویسندگان
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