کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2733625 1566729 2015 10 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Spontaneous Chronic Pain After Experimental Thoracotomy Revealed by Conditioned Place Preference: Morphine Differentiates Tactile Evoked Pain From Spontaneous Pain
ترجمه فارسی عنوان
درد مزمن خود به خودی پس از توراکوتومی تجربی که توسط مکان های مورد نظر تعیین می شود، ترجیح داده می شود: مورفین درد ناشی از تحریک تاکتیکی را از درد خود به خود متمایز می کند
کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی عصب شناسی
چکیده انگلیسی


• Experimental thoracotomy with rib retraction in the rat causes tactile allodynia.
• Systemic delivery of gabapentin or morphine can temporarily relieve this allodynia.
• Gabapentin but not morphine conditions a place-preference response.
• Thus, spontaneous pain is present at 1 to 2 weeks after thoracotomy.
• The mechanisms underlying allodynia differ from those for spontaneous pain.

Chronic pain after surgery limits social activity, interferes with work, and causes emotional suffering. A major component of such pain is reported as resting or spontaneous pain with no apparent external stimulus. Although experimental animal models can simulate the stimulus-evoked chronic pain that occurs after surgery, there have been no studies of spontaneous chronic pain in such models. Here the conditioned place preference (CPP) paradigm was used to reveal resting pain after experimental thoracotomy. Male Sprague Dawley rats received a thoracotomy with 1-hour rib retraction, resulting in evoked tactile hypersensitivity, previously shown to last for at least 9 weeks. Intraperitoneal injections of morphine (2.5 mg/kg) or gabapentin (40 mg/kg) gave equivalent 2- to 3-hour-long relief of tactile hypersensitivity when tested 12 to 14 days postoperatively. In separate experiments, single trial CPP was conducted 1 week before thoracotomy and then 12 days (gabapentin) or 14 days (morphine) after surgery, followed the next day by 1 conditioning session with morphine or gabapentin, both versus saline. The gabapentin-conditioned but not the morphine-conditioned rats showed a significant preference for the analgesia-paired chamber, despite the equivalent effect of the 2 agents in relieving tactile allodynia. These results show that experimental thoracotomy in rats causes spontaneous pain and that some analgesics, such as morphine, that reduce evoked pain do not also relieve resting pain, suggesting that pathophysiological mechanisms differ between these 2 aspects of long-term postoperative pain.PerspectiveSpontaneous pain, a hallmark of chronic postoperative pain, is demonstrated here in a rat model of experimental postthoracotomy pain, further validating the use of this model for the development of analgesics to treat such symptoms. Although stimulus-evoked pain was sensitive to systemic morphine, spontaneous pain was not, suggesting different mechanistic underpinnings.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: The Journal of Pain - Volume 16, Issue 9, September 2015, Pages 903–912
نویسندگان
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