کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2741487 1148534 2013 4 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
A dose–response study on the efficacy of tricyclic antidepressants on reducing morphine-withdrawal symptoms
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی بیهوشی و پزشکی درد
پیش نمایش صفحه اول مقاله
A dose–response study on the efficacy of tricyclic antidepressants on reducing morphine-withdrawal symptoms
چکیده انگلیسی

BackgroundAcute detoxification may lead to withdrawal syndrome. The syndrome is sufficiently aversive in those who are morphine-dependents and thus it hinders abstinence. The opioids are most often used clinically to lighten this syndrome. Here, we evaluated the effects of tricyclic antidepressants (TCAs) in treating physical dependence to opioids upon acute detoxification in mice.Materials and methodsAdult NRL mice were rendered physically dependent on morphine by increasing daily doses of subcutaneous morphine for 3 days and precipitated withdrawal jumping by subcutaneous naloxone on Day 4. The mice were then assigned to receive intramuscular saline or one of the five TCAs 1 hour prior to creating naloxone-precipitated withdrawal. The withdrawal jumping frequency in 30 minutes was counted after naloxone-precipitated withdrawal.ResultsOur results (the newest findings) based on the equimolar dose (30 μmol/kg), showed that the severity of physical dependence on morphine could be attenuated with less intramuscular TCAs [percent maximal possible effect (MPE) < 50). Amoxapine, protriptyline, amitriptyline, clomipramine, and trimipramine produced a mean percent MPE (43, 18, 37, 45, and 36, respectively); amoxapine, protriptyline, amitriptyline, and clomipramine, also produced a dose-related effect on attenuating the severity of morphine dependence, but not trimipramine. A higher dose had a stronger effect.ConclusionAmoxapine, trimipramine, protriptyline, amitriptyline, and clomipramine could have a lightening effect on physical dependence on morphine.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Acta Anaesthesiologica Taiwanica - Volume 51, Issue 1, March 2013, Pages 18–21
نویسندگان
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