کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2741489 | 1148534 | 2013 | 6 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
The role of HMGB1 in inflammation-mediated organ injury
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موضوعات مرتبط
علوم پزشکی و سلامت
پزشکی و دندانپزشکی
بیهوشی و پزشکی درد
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: The role of HMGB1 in inflammation-mediated organ injury The role of HMGB1 in inflammation-mediated organ injury](/preview/png/2741489.png)
چکیده انگلیسی
HMGB1 is a chromosome-binding protein that also acts as a damage-associated molecular pattern molecule. It has potent proinflammatory effects and is one of key mediators of organ injury. Evidence from research has revealed its involvement in the signaling mechanisms of Toll-like receptors and the receptor for advanced glycation end-products in organ injury. HMGB1-mediated organ injuries are acute damage including ischemic, mechanical, allograft rejection and toxicity, and chronic diseases of the heart, kidneys, lungs, and brain. Strategies against HMGB1 and its associated cellular signal pathways need to be developed and may have preventive and therapeutic potentials in organ injury.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Acta Anaesthesiologica Taiwanica - Volume 51, Issue 1, March 2013, Pages 28–33
Journal: Acta Anaesthesiologica Taiwanica - Volume 51, Issue 1, March 2013, Pages 28–33
نویسندگان
Paladd Asavarut, Hailin Zhao, Jianteng Gu, Daqing Ma,