کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2746782 | 1148887 | 2007 | 6 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Bénéfices potentiels des traitements non anti-infectieux du choc septique : analyse critique de la littérature
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کلمات کلیدی
موضوعات مرتبط
علوم پزشکی و سلامت
پزشکی و دندانپزشکی
بیهوشی و پزشکی درد
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Bénéfices potentiels des traitements non anti-infectieux du choc septique : analyse critique de la littérature Bénéfices potentiels des traitements non anti-infectieux du choc septique : analyse critique de la littérature](/preview/png/2746782.png)
چکیده انگلیسی
Among numerous non anti-infective treatments proposed in the management of severe sepsis and septic shock, early administration of steroids and recombinant human activated protein C are the most studied and the major source of debate. Patients with functional adrenal insufficiency appear to be the best cases for early treatment with low doses of hydrocortisone. However, definition of adrenal dysfunction, interpretation of cortisol blood concentration and its appropriateness, investigation of the hypothamalo-pituitary-adrenal axis and value of corticotropin stimulation test are matter of discussion. Similarly, recombinant human activated protein C might be beneficial in patients with severe sepsis and septic shock but the results of clinical trials are controversial. Structure of the PROWESS pivotal study, post hoc analyses of numerous subgroups, use of severity scoring system for selection of the patients, unproven mechanisms of action of activated Protein C, interactions with combined treatments represent major sources of confusion and of debate in the analysis of the trials. Non anti-infective treatments should be considered in selected patients when appropriate conventional treatments have been implemented. Use of these new treatments should bring additional improvement in the prognosis in severely ill patients at high risk of death.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Annales Françaises d'Anesthésie et de Réanimation - Volume 26, Issue 4, April 2007, Pages 370-375
Journal: Annales Françaises d'Anesthésie et de Réanimation - Volume 26, Issue 4, April 2007, Pages 370-375
نویسندگان
P. Moine,