کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2754222 1404220 2016 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Prognostic Effect of Low Subcutaneous Adipose Tissue on Survival Outcome in Patients With Multiple Myeloma
ترجمه فارسی عنوان
اثر پیش آگهی کم شنوایی پوستی بر میزان بروز بقای بیماران مبتلا به میلوم چندگانه
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی بیهوشی و پزشکی درد
چکیده انگلیسی

BackgroundIncreasing evidence suggests that decreased skeletal muscle mass (sarcopenia) or adipose tissue assessed using computed tomography (CT) predicts negative outcomes in patients with solid tumors. However, the prognostic value of such an assessment in multiple myeloma (MM) remains unknown.Patients and MethodsConsecutive patients with newly diagnosed symptomatic MM were retrospectively analyzed. The cross-sectional area of skeletal muscles and subcutaneous or visceral adipose tissue was measured using CT. Body composition indexes (skeletal muscle index, subcutaneous adipose tissue index [SAI], and visceral adipose tissue index) were calculated. The association between these indexes and overall survival (OS) was examined.ResultsOf 56 evaluable patients, 37 (66%) had sarcopenia. The 2-year OS in patients with SAI < median was 58% compared with 91% in those with SAI ≥ median (P = .006). In multivariate analyses, SAI < median was significantly associated with poor OS (hazard ratio, 4.05; P = .02). Sarcopenia was not associated with OS. The maximum value of the standardized uptake value was significantly higher in patients with SAI < median (P = .02).ConclusionThe findings of this study suggest that low subcutaneous adipose tissue at baseline predicts poor survival outcome in patients with MM.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Clinical Lymphoma Myeloma and Leukemia - Volume 16, Issue 8, August 2016, Pages 434–441
نویسندگان
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