کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2760089 1150166 2011 10 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Tranexamic Acid Is Associated With Less Blood Transfusion in Off-Pump Coronary Artery Bypass Graft Surgery: A Systematic Review and Meta-analysis
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی بیهوشی و پزشکی درد
پیش نمایش صفحه اول مقاله
Tranexamic Acid Is Associated With Less Blood Transfusion in Off-Pump Coronary Artery Bypass Graft Surgery: A Systematic Review and Meta-analysis
چکیده انگلیسی

ObjectiveTranexamic acid reduces blood loss and transfusion in on-pump coronary artery bypass graft (CABG) surgery. Compared with on-pump, off-pump surgery is associated with less blood loss and transfusion. Therefore, tranexamic acid may be less effective for off-pump surgery, and its safety profile may be different in this setting. The aim of this study was to determine the efficacy and safety of tranexamic acid for off-pump CABG surgery.DesignSystematic review and meta-analysis.SettingUniversity of Edinburgh.InterventionsThe administration of tranexamic acid.MethodsA systematic review of randomized controlled trials administering tranexamic acid to patients undergoing off-pump CABG surgery. A meta-analysis of 24-hour blood loss, postoperative allogeneic transfusion, and thromboembolic events.Measurements and Main ResultsEight trials were identified. The lack of appropriate data limited the meta-analysis on blood loss. Tranexamic acid significantly reduced the overall risk of allogeneic blood component transfusion (risk ratio = 0.47; 95% confidence intervals, 0.33-0.66; p < 0.0001) and packed red blood cell transfusions (risk ratio = 0.51; 95% CI, 0.36-0.71; p = 0.0001). No association was found between tranexamic acid and myocardial infarction, stroke, or pulmonary embolism. Population sizes of meta-analyses ranged from 466 to 544.ConclusionsTranexamic acid reduces blood transfusion after off-pump surgery. Although no association with adverse events was found, the population sample size was too small to detect rare but clinically significant adverse events. A well-designed randomized controlled trial with an appropriate sample size is required to confirm tranexamic acid effectiveness and safety in off-pump CABG surgery.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Cardiothoracic and Vascular Anesthesia - Volume 25, Issue 1, February 2011, Pages 26–35
نویسندگان
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