کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2760142 | 1150167 | 2009 | 5 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: Cardiopulmonary Bypass Increases Endogenous Carbon Monoxide Production Cardiopulmonary Bypass Increases Endogenous Carbon Monoxide Production](/preview/png/2760142.png)
ObjectiveEndogenous carbon monoxide (CO) production results from heme metabolism catalyzed by heme oxygenase (HO) enzymes of which HO-1 is inducible by oxidative stress. Cardiopulmonary bypass provokes oxidative stress associated with systemic and pulmonary inflammatory responses. Therefore, the authors hypothesized that cardiopulmonary bypass is associated with an increase in endogenous carbon monoxide production.DesignA prospective, observational study.SettingA cardiothoracic operating room.ParticipantsForty patients undergoing cardiac surgery with cardiopulmonary bypass.InterventionsNone.Measurements and Main ResultsEnd-tidal CO levels and arterial carboxyhemoglobin concentrations were measured before and after cardiopulmonary bypass. End-tidal CO concentrations and carboxyhemoglobin levels were increased significantly after cardiopulmonary bypass as compared with prebypass values (median [interquartile range]: end-tidal CO levels: 33 [20-42] ppm v 22 [16-32] ppm, p < 0.01; carboxyhemoglobin 1.3% [1.0%-1.3%] v 0.9% [0.6%-1.0%], p < 0.01). To exclude that the observed increases were caused by CO accumulation during CPB, the authors also assessed carboxyhemoglobin concentrations in the arterial and venous limb of the oxygenator, indicating that CO is eliminated across the membrane oxygenator during CPB.ConclusionsCardiac surgery with cardiopulmonary bypass is associated with an increase in endogenous CO production.
Journal: Journal of Cardiothoracic and Vascular Anesthesia - Volume 23, Issue 6, December 2009, Pages 802–806