History of Post-traumatic Stress Disorder Is Associated With Impaired Neuropsychometric Performance After Coronary Artery Surgery

ObjectiveTo determine if preoperative history of post-traumatic stress disorder (PTSD) is associated with postoperative cognitive impairment.DesignAn observational study.SettingVeterans Affairs Medical Center.ParticipantsCardiac surgical patients.InterventionsNone.Measurements and Main ResultsAge- and education-balanced patients (≥55 years of age) undergoing cardiac surgery (n = 30 with a history of PTSD+, n = 56 without a history of PTSD−) and nonsurgical controls (n = 28) were recruited. Recent verbal and nonverbal memory and executive functions were assessed before and 1 week after cardiac surgery or at 1-week intervals in nonsurgical controls. Demographic and medical parameters were similar between groups with the exception of preoperative depression and a history of alcohol dependence. Preoperative depression scores were significantly (p = 0.02) higher in PTSD+ compared with PTSD− groups. Immediate Word List Recall and Delayed Word List Recall under baseline conditions were worse in PTSD+ compared with PTSD− patients. Cognitive performance after surgery decreased by at least 1 standard deviation in 27 PTSD− patients (48%) and in 25 PTSD+ patients (83%) (p = 0.002) versus nonsurgical controls. Multivariate regression analysis (including a history of depression and alcohol dependence) revealed that a history of PTSD was significantly associated with overall (including nonverbal recent memory, verbal recent memory, and executive functions) postoperative cognitive dysfunction (p = 0.005).ConclusionsThe current findings suggest that patients with a history of PTSD undergoing coronary artery surgery using cardiopulmonary bypass may be especially vulnerable to postoperative cognitive impairment.