کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2760285 1150170 2013 10 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Hypertonic Solution Decreases Extravascular Lung Water in Cardiac Patients Undergoing Cardiopulmonary Bypass Surgery
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی بیهوشی و پزشکی درد
پیش نمایش صفحه اول مقاله
Hypertonic Solution Decreases Extravascular Lung Water in Cardiac Patients Undergoing Cardiopulmonary Bypass Surgery
چکیده انگلیسی

ObjectiveTo test the hypothesis that the infusion of hypertonic solution would decrease extravascular lung water postoperatively and thus improve pulmonary function.DesignProspective, randomized, blinded trial.SettingTertiary cardiothoracic referral center.ParticipantsTwenty-six patients with coronary artery disease who underwent surgery with cardiopulmonary bypass (CPB).InterventionsPatients were allocated randomly to receive 4 mL/kg of 7.2% NaCl/hydroxyethyl starch, 200/0.5 (HSH group) or an equal volume of 0.9% NaCl (control group) for 30 minutes starting after anesthesia induction. The extravascular lung water index, hemodynamic and biochemical data, and the rate of complications were analyzed.Measurements and Main ResultsThe extravascular lung water index was significantly lower (7 v 9.5 mL/kg) in the HSH group at the first postoperative day (p < 0.01). The index of arterial oxygenation efficiency was significantly higher at 5 minutes and 2 and 4 hours after cardiopulmonary bypass (CPB) in the HSH group (p < 0.05). The alveolar-arterial oxygen tension difference was significantly lower at 5 minutes and 2 and 4 hours after CPB in the HSH group (p < 0.01). The cardiac index was significantly higher at 5 minutes after infusion in the HSH group (p < 0.05).ConclusionsThe infusion of HSH leads to significant decreases in the extravascular lung water index during and after cardiac surgery and is associated with better preservation of pulmonary function and transient increases in the cardiac index. Further trials are needed to clarify the clinical advantages of hypertonic solution administration in patients undergoing surgery with CPB.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Cardiothoracic and Vascular Anesthesia - Volume 27, Issue 2, April 2013, Pages 273–282
نویسندگان
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