کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2760806 1150182 2009 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
B-Type Natriuretic Peptide as a Predictor of Postoperative Heart Failure After Aortic Valve Replacement
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی بیهوشی و پزشکی درد
پیش نمایش صفحه اول مقاله
B-Type Natriuretic Peptide as a Predictor of Postoperative Heart Failure After Aortic Valve Replacement
چکیده انگلیسی

ObjectiveB-type natriuretic peptide (BNP) has been established as a biomarker for heart failure. The objective was to evaluate BNP measured on arrival in the intensive care unit (ICU) as a predictor for heart failure defined as need for inotropic support or IABP beyond 24 hours postoperatively after aortic valve replacement.DesignA prospective, observational study.SettingA cardiothoracic surgery unit at a tertiary level hospital.ParticipantsOne hundred sixty-one patients undergoing aortic valve replacement.Measurements and Main ResultsTwo levels of BNP were evaluated: the median (BNP >133 pg/mL) and a cutoff (BNP >82 pg/mL) based on receiver-operating characteristic (ROC) analysis. Uni- and multivariate analysis were performed to identify predictors of postoperative heart failure. Patients with postoperative heart failure (n = 37) showed a more than 10-fold increase in 30-day mortality (8.1%, 3/37) compared with patients without postoperative heart failure (0.8%, 1/124) (p = 0.038). Elevated postoperative BNP levels were identified as an independent predictor of postoperative heart failure: BNP >82 pg/mL (p = 0.004) and BNP >133 pg/mL (p = 0.013). The area under the ROC curve for BNP as a predictor of postoperative heart failure was 0.69.ConclusionPostoperative heart failure after aortic valve replacement is still a very serious condition with increased early mortality. The results of the present study suggest that an elevated BNP level on arrival in the ICU is an independent predictor of postoperative heart failure after aortic valve replacement. In the authors' opinion, an increased BNP level on arrival in the ICU may support early diagnosis and allow optimal management of heart failure after aortic valve replacement.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Cardiothoracic and Vascular Anesthesia - Volume 23, Issue 2, April 2009, Pages 161–165
نویسندگان
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