کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2760807 1150182 2009 4 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Is C-Reactive Protein a Biomarker for Immediate Clinical Outcome After Cardiac Surgery?
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی بیهوشی و پزشکی درد
پیش نمایش صفحه اول مقاله
Is C-Reactive Protein a Biomarker for Immediate Clinical Outcome After Cardiac Surgery?
چکیده انگلیسی

ObjectiveThe purpose of this study was to determine the possible correlation between inflammatory activation after cardiac surgery with cardiopulmonary bypass, measured by postoperative C-reactive protein concentrations, and immediate intensive care unit outcome.DesignA prospective, clinical cohort study.SettingA 10-bed surgical intensive care unit at a tertiary university hospital.PatientsTwo hundred sixteen consecutive patients undergoing nonemergency cardiac surgery with cardiopulmonary bypass.Measurements and Main ResultsParsonnet and Acute Physiology and Chronic Health Evaluation scores, characteristics of the surgical intervention, intensive care unit length of stay, and mortality were recorded along with the following variables: cardiac (hours requiring inotropic support and new atrial fibrillation), respiratory (oxygenation index and hours requiring intubation), renal (difference between serum creatinine at admission and maximum creatinine), and analytic (C-reactive protein at admission and 6, 24, and 48 hours later; troponin I; CK-MB; and lactate).ResultsPostoperative C-reactive protein concentrations did not correlate with variables such as time requiring inotropic support or intubation, oxygenation index, delta serum creatinine, and intensive care unit length of stay (with the exception of cardiopulmonary bypass time and the more frequent norepinephrine requirement in patients with higher C-reactive protein concentration at 48 hours); nor did C-reactive protein correlate with the analytic variables (with the exception of the lactate peak and C-reactive protein concentrations at 24 and 48 hours). There was no correlation between C-reactive protein and postoperative variables for coronary artery bypass graft surgery and valvular groups analyzed separately.ConclusionPostoperative C-reactive protein does not seem to be a useful marker in predicting outcome after 48 hours in the intensive care unit.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Cardiothoracic and Vascular Anesthesia - Volume 23, Issue 2, April 2009, Pages 166–169
نویسندگان
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