Phosphodiesterase III Inhibition Affects Platelet-Monocyte Aggregate Formation Depending on the Axis of Stimulation

Conclusions: These findings suggest that the effects of PDE3 inhibition on platelets and monocytes are modified by the type of stimulation and only partially suppress the inflammatory response of platelets and monocytes. The increase in platelet-monocyte conjugates in unstimulated and FMLP-stimulated blood suggested that PDE3 inhibition may also trigger proinflammatory reactions.