Chronic Intrathecal Infusion of Minocycline Prevents the Development of Spinal-Nerve Ligation-Induced Pain in Rats

In this study, the authors demonstrate the preventive effect of continuous intrathecal minocycline on the development of nociceptive behaviors induced by L5/6 spinal-nerve ligation in rats. Further studies are required to examine if continuous intrathecal minocycline could be used safely in the clinical setting.