Evaluation of the Effect of Perioperative Rofecoxib Treatment on Pain Control and Clinical Outcomes in Patients Recovering From Gynecologic Abdominal Surgery: A Randomized, Double-Blind, Placebo-Controlled Clinical Study

Compared with placebo, perioperative administration of rofecoxib 50 mg provided significant opioid sparing, significantly better pain control, improved clinical outcomes, and was well tolerated.