کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2771199 | 1151678 | 2007 | 6 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Impact of phosphodiesterase 4D on cardiac β2 adrenergic receptor signaling
دانلود مقاله + سفارش ترجمه
دانلود مقاله ISI انگلیسی
رایگان برای ایرانیان
کلمات کلیدی
موضوعات مرتبط
علوم پزشکی و سلامت
پزشکی و دندانپزشکی
بیهوشی و پزشکی درد
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Impact of phosphodiesterase 4D on cardiac β2 adrenergic receptor signaling Impact of phosphodiesterase 4D on cardiac β2 adrenergic receptor signaling](/preview/png/2771199.png)
چکیده انگلیسی
Cyclic adenosine monophosphate (cAMP) is an important intracellular second messenger whose levels are tightly regulated within intracellular subdomains. Generation, detection, and degradation of cAMP is influenced by signaling complexes localized to specific regions of the cell by scaffolding proteins, such as muscle A kinase-anchoring protein (mAKAP). The distribution of cAMP within myocytes differs after β1 adrenergic receptor (β1AR) activation relative to β2AR activation as a result of differences in the interaction of these receptor subtypes with signaling complexes. β1AR stimulation generates a global increase in cAMP, whereas β2AR stimulation elicits a cAMP increase only within restricted areas of the cell. Phosphodiesterase 4D (PDE4D) plays an important role in this process.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Seminars in Anesthesia, Perioperative Medicine and Pain - Volume 26, Issue 1, March 2007, Pages 22-27
Journal: Seminars in Anesthesia, Perioperative Medicine and Pain - Volume 26, Issue 1, March 2007, Pages 22-27
نویسندگان
Andrew J. MD, PhD, Nathan Pearl, Christine Chang,